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Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

RecruitingNAAges 18 Years - anyAllAin Shams University
NCT06995690 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia. * Both Sexes. * Patients aged equal to or above 18 years. * Body mass index \<35 kg/m2 * Duration of operation from 1 hour to 3 hours Exclusion Criteria: * Patients' refusal of procedure or participation in the study. * Patients with contraindication to spinal anesthesia. * Patients with cardiovascular or pulmonary disease. * Patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmHg and/or mean arterial pressure less than 60 mmHg). * Patients aged below 18 years. * Duration of operation below 1 hour or above 3 hours.
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What it tests

  • Ketamine
  • Normal Saline
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Where

1 site
Ain Shams University Hospitals
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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