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Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia

RecruitingNAAges 18 Years - anyAllAssiut University
NCT06996834 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute exacerbations of community-acquired pneumonia (CAP) accompanied by hypoxemic respiratory failure. The primary focus is on assessing treatment failure within 48 hours, defined as the need for intubation or death. Secondary outcomes include evaluations of gas exchange parameters, patient comfort levels, duration of ICU stay, and 28-day mortality rates.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Clinical and radiographic diagnosis of CAP * Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen/fraction of inspired oxygen ratio (PaO₂/FiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25/min * Informed consent obtained Exclusion Criteria: * Hemodynamic instability requiring vasopressors * Altered mental status Glasgow Coma Scale (GCS \< 13) * Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery) * Do-Not-Intubate (DNI) order
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What it tests

  • Non-Invasive ventilation (NIV)
  • High Velocity Nasal Insufflation
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Where

1 site
Assuit University
Asyut, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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