Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients

Inclusion Criteria: * Pediatric patients (\<18 years old) who are candidates to receive intestinal or lung transplantation (before SOT). * Pediatric (\<18 years old) or adult patients (≥18 years old) who are either candidates for renal transplantation or have already undergone renal transplantation and remain candidates for subsequent HSCT. * Patients who provide informed consent (or their legal guardians in the case of minors) before any study-related procedures. * Recipients should have no active infectious disease or other medical condition that would contraindicate the combined transplantation procedure, as determined by the investigational team. Exclusion Criteria: * Recipients with existing bone marrow disorders or those receiving medications known to adversely affect bone marrow function. * Patients with advanced organ dysfunction (hepatic, cardiac, or pulmonary) incompatible with successful combined transplantation. * Patients with active or uncontrolled autoimmune conditions that may interfere with transplantation and the induction of chimerism. * Patients with known allergies to medications or products required for conditioning or transplantation. * Patients with severe psychiatric or cognitive disorders that may interfere with adherence to study instructions or postoperative care. * Patients currently enrolled in another clinical trial that could interfere with the outcomes or safety of this study. * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test. * Any other condition that, in the opinion if the Investigator, may interfere with the efficacy and/or safety evaluation of the trial.