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Treatment of Retinal Detachment in People Who Have Not Had Cataract Surgery With Vitrectomy vs Vitrectomy and Cataract Removal

RecruitingPhase 3Ages 50 Years - anyAllQueen's University, Belfast
NCT06997874 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background and study aims The retina is the layer at the back of the eye that allows us to see. Sometimes, it can detach from the wall of the eye, causing a condition called rhegmatogenous retinal detachment (RRD), which leads to vision loss and requires surgery. The most common surgery for RRD is vitrectomy, but this can lead to complications like cataracts, which worsen over time and need to be removed with another surgery. Cataract surgery involves replacing the cloudy lens with a clear artificial one. Currently, it's unclear whether it's better to perform both surgeries at the same time or separately. The COMBAT study aims to find out which approach is best by comparing the outcomes of patients who have vitrectomy alone versus those who have both surgeries (vitrectomy and cataract surgery by phacoemulsification and intraocular lens \[IOL\] implantation) together. Who can participate

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults ≥50 years of age * Non-highly myopic (\< -6 diopters; ≤26.5 mm axial length) phakic RRD * Naive to previous vitreoretinal surgery * Pars plana vitrectomy is planned to repair their RRD Exclusion Criteria: * Presence of a "formed/established cataract." A "formed/established cataract" is defined as a cataract that, based on the Age-Related Eye Disease Study (AREDS) Research Group, is graded as nuclear sclerosis of \>3 and/or if there is an anterior cortical cataract and/or a subcapsular posterior cataract involving the visual axis. * Pseudophakia or aphakia * High myopia (≥ -6 diopters; \>26.5 mm axial length) * Giant retinal tear (i.e. presence of one or more retinal tears of \>3 clock hours in size) * Retinal dialysis * Inclusion in an investigational drug study * Declined consent for participation
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What it tests

  • Phacovitrectomy
  • Vitrectomy
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Where

31 sites
Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom
Belfast Health and Social Care Trust
Belfast, United Kingdom
Sandwell and West Birmingham Hospitals NHS Trust
Birmingham, United Kingdom
Bradford Teaching Hospitals NHS Foundation Trust
Bradford, United Kingdom
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
County Durham and Darlington NHS Foundation Trust
Darlington, United Kingdom
NHS Lothian
Edinburgh, United Kingdom
NHS Greater Glasgow & Clyde
Glasgow, United Kingdom

…and 23 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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