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Quadriceps Motor Unit Adaptation to Simulated Knee Injury

RecruitingEARLY Phase 1Ages 18 Years - 30 YearsAllUniversity of Central Florida
NCT06999057 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18-30 years 2. Physically active (Tegner ≥ 5) 3. No prior lower-limb surgery or major injury Exclusion Criteria: 1. Lower limb surgery or significant injury in past 2 years 2. Cardiopulmonary, neurological, or psychiatric disorders 3. Needle/electrical stimulation anxiety 4. Medications affecting neuromuscular or psychological function 5. Pregnancy 6. Allergic to lidocaine 7. Inability to elicit Hoffmann reflex
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What it tests

  • Joint Effusion via 60 mL Sterile Saline
  • Intra-articular Lidocaine
  • Sham injection
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Where

1 site
University of Central Florida
Orlando, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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