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Exploring the Utility of [18F]3F4AP for Demyelination Imaging

RecruitingPhase 1Ages 18 Years - 90 YearsAllYale University
NCT06999434 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The overall objective is to obtain an assessment of the pharmacokinetics of \[18F\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).

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📋 Eligibility rules (as published)
Inclusion: 1. Male and Female subjects must be ≥18 and \<90 years of age; 2. Able to understand and provide informed consent prior to study procedures 3. Must be in good health Exclusion: 1. Less than 18 years of age; 2. Pregnant or breastfeeding; 3. Any significant systemic illness or unstable medical condition; 4. Pre-existing medical conditions or claustrophobic reactions; 5. Research-related radiation exposure exceeds current PET Center guidelines (i.e. 50 mSv in the prior 12 months); 6. History of a bleeding disorder or are currently taking anticoagulants.
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What it tests

  • [ 18F]3F4AP
  • [18F]MK6240
  • [11C]PIB
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Where

1 site
Yale University PET Center
New Haven, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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