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Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia

RecruitingPhase 2Ages 65 Years - anyAllInstitute of Hematology & Blood Diseases Hospital…
NCT07010237 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospetive,Single-Center, Single-Arm, Phase IIB Clinical Study.This study aims to evaluate the efficacy and safety of dose-attenuated IST combined with Hetrombopag in elderly patients (≥65 years) with VSAA/SAA.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinical diagnosis of VSAA/SAA. * Age ≥65 years. * Completion of all screening assessments. * Must be able to swallow tablets. * Signed informed consent (by patient or legal guardian if patient is incapacitated). Exclusion Criteria: * Clonal cytogenetic abnormalities (excluding isolated -Y or +8). * Prior treatment with ATG/high-dose cyclophosphamide. * Prior cyclosporine/tacrolimus use \>12 months. * Prior TPO-RA therapy \>3 months. * Uncontrolled malignancies or conditions contraindicating ATG. * Severe organ dysfunction (e.g., creatinine ≥177 μmol/L). * Investigator judgment of unsuitability.
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What it tests

  • Dose-attenuated IST and Hetrombopag
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Where

1 site
Red Blood Cell Diseases Center
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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