Study of CM512 Injection in Subjects With Moderate-to-severe Asthma

Inclusion Criteria: * Able to understand and comply with procedures of the protocol, and voluntarily sign the Informed Consent Form. * Age ≥ 18 years old and ≤ 75 years old. * Body mass index (BMI) ≥ 18.0 kg/(m\*m). * Documented treatment with medium to high dose Inhaled Corticosteroids (ICS) in combination with asthma controller medication for at least 3 months with a stable dose ≥1 month prior to Visit 1. * Documented history of at least 1 severe asthma exacerbation events within 12 months, and at least one of the exacerbations should occur during the treatment of medium-to-high dose ICS. * Asthma Control Questionnaire-6 (ACQ-6) score ≥1.5 Exclusion Criteria: * Women of childbearing potential have a positive pregnancy test result during the screening period; women who are pregnant or lactating. * With a history of drug abuse within the past 5 years before screening visit. * Allergic or intolerant to CM512 injection or placebo components, or with a history of severe drug allergies or anaphylactic shock. * With any medical or non-medical conditions that are not suitable for participation in this study by investigators.