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Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

RecruitingEARLY Phase 1Ages 18 Years - anyAllAdvanced Reconstructive Surgery Alliance
NCT07012642 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which can worsen lymphedema. Although anecdotal evidence suggests benefits of GLP-1 RAs for lymphedema patients, rigorous prospective studies are lacking. This study aims to evaluate the effectiveness of GLP-1 RAs in improving quality of life and clinical outcomes in lymphedema patients, thereby addressing a critical gap in literature and potentially offering a new treatment option.

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📋 Eligibility rules (as published)
Inclusion Criteria: Adults 18 years or older with unilateral upper or lower extremity lymphedema Limb volume \> 5% BMI =\> 23 Oncology clearance if there is a cancer history Exclusion Criteria: Moderate to severe venous insufficiency Actively using GLP-1 RAs Known intolerance or adverse effect to GLP-1 RAs Medical history or morbidity where GLP-1 RAs are contraindicated as per patient's primary care provider such as MEN syndrome or history of thyroid cancer.
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What it tests

  • GLP-1 Receptor Agonists
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Where

2 sites
River Center
Red Bank, United States
260 Old Hook Rd Suite 304
Westwood, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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