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Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3Ages 18 Years - anyAllIDEAYA Biosciences
NCT07015190 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma (OptimUM-10)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary non-metastatic uveal melanoma * Able and willing to provide written, informed consent before initiation of any study-related procedures, and in the opinion of the Investigator, to comply with all study requirements * ECOG 0 or 1 * Adequate organ function Exclusion Criteria: * Previous treatment for UM * Evidence of metastatic UM * Attributes that necessitate enucleation regardless of response to therapy * Evidence of progressive secondary underlying ocular disease that would confound longitudinal VA assessments * Presence of a malignant disease other than the one being treated in this study
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What it tests

  • Darovasertib
  • Primary Local Therapy
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Where

94 sites
Mayo Clinic Scottsdale - PPDS
Scottsdale, United States
UCSD Moores Cancer Center
La Jolla, United States
Jules Stein Eye Institute
Los Angeles, United States
USC Norris Comprehensive Cancer Center
Los Angeles, United States
University of California Irvine Medical Center
Orange, United States
Stanford Comprehensive Cancer Center
Palo Alto, United States
Kaiser Permanente-Riverside Medical Center
Riverside, United States
UCSF Wayne and Gladys Valley Center for Vision
San Francisco, United States

…and 86 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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