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Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms

RecruitingNAAges 18 Years - 65 YearsAllUniversity of Liege
NCT07017257 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity. Currently, effective treatments for PPCS are limited, despite their lasting and debilitating impact. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, holds promise as a therapeutic option by leveraging the bottom-up modulation of brain activity via the auricular branch of the vagus nerve. This study aims to evaluate the neurophysiological and clinical effects of taVNS on brain activity and symptomatology in patients with PPCS through a randomized, controlled, double-blind trial.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 65; * Between 4 weeks and 1-year post-diagnosis of a concussion; * Score equal or above 16 on the Rivermead Post-Concussion Questionnaire; * Intact skin at the electrode site. Exclusion Criteria: * History of chronic neurological or psychological disorders (still untreated 6 months preceding inclusion); * Pregnancy or breastfeeding; * Presence of an active implant (e.g., pacemaker, cochlear implant); * History of myocardial infarction or cardiac arrhythmia; * Excessive alcohol consumption (\> 14 drinks per week) and/or drug (\> 1x/week) use within the past 6 months.
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What it tests

  • Active taVNS
  • Sham taVNS
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Where

1 site
University Hospital of Liège
Liège, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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