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Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region

Recruitingn/aAges 9 Years - anyAllCentre de Recherche Médicale de Lambaréné
NCT07017803 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens. It is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All GeneXpert positive TB patients and participants who provide written informed consent will be screened for the study. Participants aged above 8 who can provide sputum will also be screened. * Patients enrolled in the tuberculosis epidemiology (TB-EPI) study and eligible for MESTCAR will be enrolled without any additional consent form as the data to be collected for the two studies will be shared and no additional process is needed. Exclusion Criteria: * Samples which do not meet the quality criteria. * Samples not enough to perform all of the laboratory process * Samples contaminated
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What it tests

  • Not listed
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Where

8 sites
Centre Hospitalier Régional Georges Rawiri
Lambaréné, Gabon
Hôpital Albert Schweitzer
Lambaréné, Gabon
Hôpital de Nkembo
Libreville, Gabon
Centre Hospitalier Régional de Makokou
Makokou, Gabon
Centre de Traitement Ambulatoire (CTA) de Mouila
Mouila, Gabon
Hôpital de Bongolo
Mouila, Gabon
Centre Hospitalier Régional d'Oyem
Oyem, Gabon
Centre Hospitalier Régional Tchégué
Port-Gentil, Gabon
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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