SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)

Inclusion Criteria: Patients: 1. Able to understand and provide a written informed consent prior to any study procedures 2. Male or non-pregnant female, ≥18 years of age 3. Patient is willing to refrain from extensively washing (including bathing, swimming) the target lesional skin 12 hours before every study visit day. 4. Patient is willing and able to comply with the study protocol 5. Female participants are willing to not get pregnant between M0 until M12, from study entry to the last study visit 6. The patient is willing to start the prescribed treatment. Disease-specific inclusion criteria For patients with AD: To be eligible to participate in this study, a subject must meet all of the following criteria: 6\. Diagnosis and history of chronic, moderate-to-severe AD (by the Eichenfield revised criteria of Hanifin and Rajka for at least 3 years before baseline visit. 7\. Documented recent history (last 6 months) of eligibility for (local or systemic) treatment with immunosuppressants, biologics or JAK-inhibitors. 8\. When applicable, documented recent history (last 6 months) of inadequate response to treatment with topical therapy, immunosuppressants, biologics or JAK-inhibitors. 9\. Current treatment can include moisturizers, topical treatment and/or systemic treatments with preferable wash-out (see exclusion criterion #9). On-study treatment is at physician and patient discretion but must include eligibility to starting new systemic treatment. 10\. EASI≥7 (moderate-to-severe disease) 11. At least one suitable target lesion at the discretion of the investigator 12. Intention to start treatment with cyclosporine A, dupilumab, tralokinumab, lebrikizumab or a JAK1-inhibitor (abrocitinib or upadacitinib) For patients with CLE: Participants must have a diagnosis of CLE, including SCLE, CDLE or LET that fulfil the following: 6\. Confirmed CLE diagnosis by clinicopathological correlation. 7. An overall CLE Disease Area and Severity Index Activity (CLASI-A) Score ≥3 without counting any diffuse alopecia or oral ulcers. 8\. Intention to start treatment with TCS, hydroxychloroquine or methotrexate (combination or mono-treatment). If participating in the exploratory study with the skin biopsy: location of the lesion(s) selected for biopsy preferably outside the facial area (possible are e.g., neck, chest, back, limbs, scalp, ear etc.). For patients with CSU: 6\. Diagnosis of CSU (moderate to severe according to international guidelines (Zuberbier et al, 2022)) for ≥3 months and symptomatic disease despite treatment with second generation H1 antihistamines (up to fourfold the approved dose). 7.Patients currently on an antihistamine (up to fourfold the approved dose) must be on a stable dose for at least 2 weeks prior to day 1 and must maintain the same stable dose throughout the treatment period. 8\. Intention to start (add-on to antihistamine) treatment of omalizumab, cyclosporine A or BTK inhibitor\*. (\*when approved and reimbursed in NL) For patients with HS: 6\. Patient with a history of signs and symptoms consistent with moderate-to-severe HS, based on IHS4 score (Zouboulis et al., 2017), for at least 1 year prior to baseline 7. Current treatment can include topical treatment. On-study treatment is at physician and patient discretion but must include eligibility to starting systemic treatment 8. Intention to start treatment with anti-TNF or anti-IL17 (secukinumab, bimekizumab\*) \*when approved and reimbursed in NL. For patients with MF: 6\. A confirmed diagnosis of CTCL MF type and stage classification via histology or clinicopathological correlation 7. For the stage IA-IIA CTCL patients: at least one patch and/or one plaque lesion is present 8. Intention to start treatment with topical chlormethine, topical corticosteroids or phototherapy (PUVA / UV-B). For patients with PSO: 6\. Diagnosed with chronic plaque psoriasis at least 6 months prior to study participation 7. PASI≥5 with at least one suitable target lesion at the discretion of the investigator 8. Current treatment can include moisturizers, topical treatment and/or systemic treatments with preferable wash-out. On-study treatment is at physician and patient discretion but must include eligibility to starting new systemic treatment 9. Intention to start treatment with biologics: anti-TNF, anti-IL23, anti-IL17 or anti-TYK2 Healthy volunteers: All healthy volunteers must meet all of the following inclusion criteria: 1. Signed informed consent before any study-mandated procedure. 2. Male or non-pregnant female volunteers, ≥18 years of age 3. Subject is in stable good health as per judgement of the investigator based upon the results of medical history and assessments performed at baseline. 4. No clinically significant skin disease as judged by the investigator. 5. No history of hypertrophic scarring or keloid. 6. Subject is willing to refrain from extensively washing (including bathing, swimming) the skin 12 hours before every study visit. 7. Subject is willing and able to wash out and withhold any topical treatment (prescription and over-the-counter products) in the investigational area for 2 weeks prior to Day 1. 8. Subject is willing to refrain from application of any topical product (e.g. ointments, cream, or washing lotions) on the skin 24 hours prior to every study visit day. 9. Subject is willing and able to wash out any antibiotic therapy for 14 days prior to Day 1. 10. Subject is willing and able to comply with the study protocol. 11. Female participants are willing to not get pregnant from study entry to the last study visit Exclusion Criteria: Patients: 1. Have any other relevant skin infection/disease in the treatment area other than the investigated skin disease. 2. Subjects who have received treatment with any non-marketed drug substance (that is, an agent which has not yet been made available for clinical use following registration) within 4 weeks prior to the baseline visit. 3. Any other c