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Health, Imaging, and Cognition Across the Menopausal Transition

Recruitingn/aAges 35 Years - 65 YearsFemaleUniversité de Sherbrooke
NCT07021664 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This observational cross-sectional study aims to better understand how the menopausal transition affects brain energy metabolism and cognition. Menopause, a natural stage in a woman's life, is typically divided into three phases: premenopause, perimenopause, and postmenopause. This transition involves hormonal fluctuations and a decline in estrogen levels, which can impact physical, emotional, and cognitive well-being. Common symptoms include hot flashes, sleep disturbances, mood changes, and difficulties with memory and concentration. Emerging evidence suggests that the decline in estrogen may impair how the brain uses glucose, its primary energy source. This reduction in glucose metabolism is thought to contribute to cognitive difficulties reported during midlife. In contrast, the brain's capacity to use ketones-alternative energy substrates produced during fasting or low-carbohydrate

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📋 Eligibility rules (as published)
Inclusion Criteria: * Able to read and speak French * Capable of understanding and signing informed consent GROUP SPECIFIC INCLUSION CRITERIA Premenopause: • Women aged 35 to 55; No change in menstrual cycle regularity over the past 10 months (variation less than 7 days per cycle) Perimenopause: Women aged 40 to 60; Menstrual cycles varying by more than 7 days per cycle for at least 10 cycles, or no period for 3 to 11 months postmenopause: Women aged 45 to 65; No menstrual period for ≥ 12 months Exclusion Criteria: * Pregnancy, childbirth within the past 12 months, or breastfeeding * Use of hormone replacement therapy or hormonal contraceptives in the past 6 months * contraindications to MRI (e.g., presence of non-compatible metallic objects) * Claustrophobia * Type 1 diabetes * Adherence to a ketogenic intervention (e.g., ketone supplements, intermittent fasting, ketogenic diet) in the past 3 months * Engaging in intense physical activity 5 times per week or more * Any significant neurological disorder (e.g., dementia, brain tumor, seizure disorder, history of significant head trauma with persistent neurological deficits, known structural brain abnormalities) * History of oophorectomy or hysterectomy * Any significant psychiatric disorder (e.g., major depression within the past 2 years, bipolar disorder, schizophrenia) * Systemic diseases or unstable/uncontrolled medical conditions (e.g., cardiovascular disease, uncontrolled diabetes, kidney or liver disorders) * Any other condition that may interfere with participation, as judged by the study physician
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What it tests

  • Not listed
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Where

2 sites
Centre de recherche sur le Vieillissement
Sherbrooke, Canada
Research Center on Aging
Sherbrooke, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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