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Determining the Optimal Dose of Intrathecal Morphine for Post-Cesarean Analgesia

RecruitingNAAges 18 Years - 50 YearsFemaleUniversity of Ioannina
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In plain words

What the trial is, and whether it could suit you

Using spinal or epidural anesthesia (known as neuraxial blocks) is the gold standard for pain control during childbirth, especially in cesarean sections (C-sections). However, many women experience moderate to severe pain after a C-section, which can affect both their physical and emotional well-being, and even impact their ability to care for their newborn. Unfortunately, this pain is often not treated effectively, which can lead to increased sensitivity to pain or even chronic postoperative pain. One effective way to manage this pain is by giving opioids directly into the spinal fluid (subarachnoid space). This method allows doctors to use much smaller doses than would be needed if the same medication were given through a vein, which also helps avoid many of the common side effects of opioids like respiratory depression, nausea, pruritus, and constipation. Common opioids used in this

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * term parturient * single pregnancy * elective cesarean delivery * adult parturient * ASA II Exclusion Criteria: * participants under the age of 18 * extreme somatometric characteristics * lack of patient consent * absolute contraindications for spinal anesthesia * urgent cesarean section * presence of known fetal anomalies * onset of labor prior to administration of the block * history of chronic pain * use of opioids (systemic or otherwise) for any reason (e.g., chronic malignant pain) * communication difficulties (e.g., language barriers, cognitive impairments) * allergy or hypersensitivity to morphine * severe arrhythmia or other serious cardiovascular conditions * severe hepatic or renal insufficiency
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What it tests

  • Intrathecal morphine
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Where

1 site
University Hospital of Ioannina
Ioannina, Greece
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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