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← Trials
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Sigh Ventilation in Cardiac Surgery

RecruitingNAAges 18 Years - anyAllZhongda Hospital
NCT07024420 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this trial is to investigate whether sigh ventilation strategy, combining sigh breaths, low tidal volume, and moderate PEEP levels, protects against major pulmonary complications within the first 7 postoperative days after cardiac surgery, as compared with conventional ventilation strategy with low tidal volume, and moderate PEEP levels.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older; * Elective cardiac surgery with cardiopulmonary bypass, aortic clamp and cardioplegia; * Written informed consent is obtained from patients and/or their legal representatives. Exclusion Criteria: * Emergence surgery; * Left ventricular assist device implantation; * Planned thoracotomy with one lung ventilation; * Undergo concurrent surgical procedures outside cardiology; * Neuromuscular illness; * Mechanical ventilation within the last 2 weeks before surgery, include CPAP and NIV; * Preoperative shock; * Preoperative Hypoxemia (PaO2\<60mmHg OR SpO2\<90% on ambient air); * Preoperative left ventricular ejection fraction \< 40%; * Systolic pulmonary artery pressure \> 50 mmHg.
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What it tests

  • Sigh Breaths
  • Low Tidal Volume
  • Moderate PEEP
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Where

1 site
Zhongda Hospital, Southeast University
Nanjing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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