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Metabolic Effect of Exercise and Diet in Endometrial Cancer Patients Eligible for Staging Surgery.

RecruitingNAAges 18 Years - 65 YearsFemaleNational Institute of Cancerología
NCT07025213 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Endometrial cancer is one of the diseases linked to obesity in women. In Mexico, about 7.6 women out of every 100,000 are diagnosed with this type of cancer, and nearly three-quarters of these women have obesity. Many women with endometrial cancer also have a condition called sarcopenic obesity, where muscle loss happens but might not be easy to identify. Researchers believe that certain molecules in the blood could help identify the health of muscles. Exercise helps muscles stay strong and healthy by affecting these molecules. For women with cancer, staying active can help maintain muscle mass, which is important for better recovery and health outcomes. This project focuses on an exercise program for women with locally advanced endometrial cancer who will be treated surgically at the National Cancer Institute of Mexico (INCan). What We Think Will Happen: Women with endome

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. -Ability to understand the nature of the study and provide written informed consent. 2. -Women aged over 18 and under 65 years. 3. -Availability to attend exercise sessions. 4. -Willingness and ability to comply with scheduled visits, the proposed nutritional algorithm, treatment plan, and laboratory tests. 5. -Histologically confirmed diagnosis of endometrioid-type endometrial cancer by biopsy. 6. -Normal electrocardiogram (ECG) result. 7. -No prior oncological treatment. 8. -Body mass index (BMI) greater than 20 kg/m². 9. -Availability of a computed tomography (CT) scan. 10. -Candidates for staging surgery. Exclusion Criteria: 1. -Patients with advanced clinical stage or stage IVB disease (according to FIGO 2018 criteria). 2. -Patients with a prior or concurrent malignancy, except non-melanoma skin cancer. 3. -Patients with uncontrolled systemic arterial hypertension. 4. -Patients with renal dysfunction (eGFR ≤ 60 mL/min/1.73 m²). 5. -Patients with uncontrolled psychiatric disorders, including claustrophobia. 6. -Patients with concurrent infections. 7. -Patients with autoimmune disease. 8. -Patients with neuromuscular disease. 9. -Contraindications to physical exercise. 10. -Vulnerable situations (e.g., homelessness preventing adherence to diet, or incarceration).
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What it tests

  • Diet and exercise.
  • Diet.
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Where

1 site
Instituto Nacional de Cancerología
México, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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