Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study)

Inclusion Criteria: 1. Diagnosed with depression/anxiety; 2. Continued use of SSris and SNris for six months prior to study start; 3. Aged between 18 and 70; 4. Confirmed cardiovascular disease (such as chronic stable coronary heart disease, heart failure, cardiomyopathy, arrhythmia, valvular heart disease, cardiac surgery, cardiac intervention, ischemia with non-obstructive coronary artery disease, etc.); 5. The patients voluntarily participated in the study, signed a written informed consent, and were willing to cooperate with the follow-up. Exclusion Criteria: 1. currently has mania or hypomania, or a history of bipolar disorder and any mental disorders (current and previous); 2. organic brain injury, etc., or serious non-cardiovascular system diseases (such as advanced cancer); 3. Unable to participate in sports training or have drug contraindications; 4. Current alcohol, drug abuse, drug use or suicidal intent; 5. Patients who were receiving other doses of eligible drugs and other antidepressants were excluded from the trial; 6. Myocardial infarction \<2 weeks or unstable angina attack period; 7. Severe and uncontrolled arrhythmia; 8. Acute heart failure stage; 9. Severe and symptomatic obstruction of the outflow tract; 10. Acute deep vein thrombosis with or without pulmonary embolism; 11. Acute myocarditis, pericarditis or endocarditis; 12. Acute aortic dissection; 13. Intracardiac thrombus with high risk of embolism; 14. Massive pericardial effusion; 15. Those who fail to exercise adequately or refuse to sign informed consent.