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Planned Delivery at 37 Versus 36 Weeks in Pregnancies With Placenta Previaand Accreta

RecruitingNAAges 18 Years - 45 YearsFemaleThe Third Affiliated Hospital of Guangzhou Medica…
NCT07025954 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Current clinical practice guidelines recommend planned cesarean delivery(CD) at 34-37 weeks of gestation in pregnant women with placenta previa and accreta. Preterm birth may lead to neonatal immaturity, while laterCD may increase the risk of severe hemorrhage and surgery complications. Retrospective studies have shown that indicated CD occurs in approximately1/3 of patients before 36 weeks, with the main trigger being antepartum hemorrhage. However, the risk of antepartum hemorrhage is lower after 36 weeks. Recent study showed that delivery shifted from 34-36 weeks to 37 weeks did not increase therisk of maternal intraoperative/postoperative hemorrhage and emergency CD. To further validate this, we propose to conduct a randomized controlled study comparing the effect of planned delivery management strategies at 37 0/7-37 6/7 weeks of gestation with those at 36 0/7-36 6/7 weekson materna

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📋 Eligibility rules (as published)
Inclusion Criteria: * 28-34 weeks of gestation. * Both ultrasound and MRI indicate placenta previa with placenta accreta spectrum (PAS). * Planned to undergo cesarean delivery at the participating study hospitals. * Agree to participate and sign the informed consent form. Exclusion Criteria: * Multiple gestation. * Other obstetric complications (e.g., preeclampsia, vasa previa), and severe maternal medical conditions (e.g., uncontrolled diabetes, progressive cardiovascular disease, active systemic lupus erythematosus, liver cirrhosis). * Major uterine structural anomalies (e.g., uterine didelphys, Uterine tumors ≥5 cm). * Estimated fetal weight \<3rd percentile for gestational age, major congenital anomalies, intrauterine fetal demise.
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What it tests

  • Cesarean delivery
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Where

6 sites
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
West China Second University Hospital, Sichuan University
Chengdu, China
Peking University Third Hospital
Beijing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Guangzhou Women and Children's Medical Center
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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