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Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals

RecruitingPhase 1Ages 18 Years - 40 YearsAllUniversidade Federal de Pernambuco
NCT07026760 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

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📋 Eligibility rules (as published)
Healthy adults aged 18-40 years, of both sexes; right-handed (confirmed via the Edinburgh Handedness Inventory); and for women, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability. Exclusion Criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions that could interfere with assessments or interventions; or use of substances that alter nervous system excitability.
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What it tests

  • Trans-spinal magnetic stimulation (90% MT + 1 Hz)
  • Trans-spinal magnetic stimulation (100% MT + 1 Hz)
  • Trans-spinal magnetic stimulation (110% MT + 1 Hz)
  • Trans-spinal magnetic stimulation (90% + 10 Hz)
  • Trans-spinal magnetic stimulation (100% MT + 10 Hz)
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Where

1 site
Universidade Federal de Pernambuco
Recife, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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