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Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT07028112 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This single-center, non interventional cohort study investigates whether chronic iron overload influences the incidence of liver complications in adults who are at least 10 years beyond allogeneic hematopoietic stem cell transplantation (allo HSCT). Approximately 400-500 survivors transplanted at Hôpital Saint Louis between January 2004 and December 2014 will be evaluated. Transplant characteristics, prior iron overload therapy, and historical hepatic events will be collected through the Promise database. At the same time, the prospective visit will include laboratory panels and non invasive liver stiffness measurement by FibroScan or shear wave elastography. The study's primary objective is to assess the impact of iron overload on the incidence of hepatic complications in patients more than 10 years after an allogeneic hematopoietic stem cell transplantation. Secondary aims include desc

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years at enrollment * Allogeneic HSCT performed at Hôpital Saint Louis between 2004/01/01 and 2014/12/31 * Alive and attending routine annual follow up within the two years of the study * Having given his non-opposition to study after understand overall aims * With health insurance coverage * Follow up consultation at Saint-Louis Hospital Exclusion Criteria: * Patient under legal protection (protection of the court, or in curatorship or guardianship). not in relapse of the hematological disease at the time of inclusion. • Patients under 45 Kg
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What it tests

  • Cohort
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Where

1 site
Hôpital Saint Louis AP-HP
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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