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โ† Trials
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Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery

RecruitingPhase 4Ages 40 Years - 80 YearsAllTongji Hospital
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In plain words

What the trial is, and whether it could suit you

Myocardial injury after noncardiac surgery (MINS) refers to postoperative elevation of cardiac troponin (cTn) levels caused by underlying ischemic mechanisms (i.e., coronary artery supply-demand imbalance or atherosclerotic thrombosis) without obvious non-ischemic causes (such as pulmonary embolism), with at least one cTn concentration exceeding the 99th percentile of the test reference upper limit, regardless of whether clinical symptoms and ECG changes are present. MINS, including myocardial infarction and ischemic myocardial injury, typically occurs within 30 days after surgery, most commonly within the first 2 postoperative days. It is an independent risk factor for 30-day postoperative mortality and is also closely associated with increased risk of mortality and vascular complications within 2 years . MINS is a common cardiovascular complication after thoracic surgery. Therefore, re

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Scheduled for elective video-assisted thoracoscopic (VATS)-assisted thoracic surgery (lobectomy, segmentectomy, wedge resection of two or more lung tissues, mediastinal tumor resection) under general anesthesia; 2. Aged 45 to 80 years (inclusive) at the time of randomization; 3. Expected postoperative hospital stay of โ‰ฅ3 days; 4. Signed a written informed consent to participate in the study. Exclusion Criteria: 1. Patients allergic to propofol, Ciprofol, or analogs of drug excipient components (soybeans, eggs, milk); 2. Patients with unstable angina; 3. Patients with congestive heart failure or hemodynamic instability requiring vasopressor agents; 4. Patients with severe COPD (FEV1 \< 1 L); 5. Glomerular filtration rate \[eGFR\] \< 30 mL/min/1.73mยฒ; 6. Patients with severe hepatic dysfunction (ALT or AST elevation exceeding 1.5 times the upper limit of normal); 7. Male or female patients planning to conceive within the next 3 months; 8. Pregnant or lactating female patients;
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What it tests

  • Propofol
  • ciprofol
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Where

1 site
Tongji hospital
Wuhan, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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