Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study

Inclusion Criteria: Among the patients requiring gastro-duodenal endoscopy, endoscopic ultrasound, or ERCP for medical purposes, the pancreatic cancer group should meet the criteria numbered 1, 2, and either 3 or 4. 1. Be at least 19 years old. 2. Have completed the informed consent for planned upper endoscopy, endoscopic ultrasound, or endoscopic retrograde cholangiopancreatography before the duodenal fluid collection. 3. A biopsy with proven stage I-IV pancreatic ductal adenocarcinoma (PDAC). 4. Suspected pancreatic cancer on imaging and scheduled for an endoscopic ultrasound-guided pancreatic biopsy. The non-pancreatic cancer group should meet the criteria numbered 1, 2, and either 3 or 4. 1. Be at least 19 years old. 2. Have completed the informed consent for planned upper endoscopy, endoscopic ultrasound, or endoscopic retrograde cholangiopancreatography before the duodenal fluid collection. 3. Patients with pancreatic cystic tumors or patients with acute or chronic pancreatitis. 4. No evidence of a pancreatic disease. Exclusion Criteria: The exclusion criteria for the pancreatic cancer and the non-pancreatic cancer groups will be: 1. Innate or post-surgical anatomy that precludes direct sampling of duodenal fluid. 2. Hemodynamically unstable and unable to have an endoscopy performed. 3. A large amount of ascites fluid that is not controlled and unable to have an endoscopy performed. 4. A coagulation disorder that cannot be corrected and unable to have an endoscopy performed.