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RADIomics to Predict HER2 Status And T-DXd Efficacy in Metastatic Breast Cancer: the RADIOSPHER2 Study

Recruitingn/aAges any - anyAllFondazione IRCCS Istituto Nazionale dei Tumori, M…
NCT07030569 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

RADIOSPHER2 study is a monocentric, retrospective, observational study aiming at identifying a radiomics signature able to predict HER2 expression (0 vs low vs overexpression) and trastuzumab deruxtecan efficacy in metastatic breast cancer patients. The study also encompasses translational analyses and inter-modal correlations in order to provide novel insights about HER2 spatial and temporal heterogeneity, at the macroscopic and microscopic levels.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with metastatic breast cancer underwent a liver, lung, pleural or bone biopsy in the metastatic setting, performed from 01Jan2005 to 01Jan2024. Exclusion Criteria: * Not available imaging (CT scan and/or PET-FdG scan) in the three months before the biopsy or before the last previous treatment interruption; * Unknown HER2 status; * Node, soft tissue or other visceral as biopsy site.
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What it tests

  • Trastuzumab deruxtecan (DS-8201a)
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Where

1 site
Fondazione IRCCS Istituto Nazionale Tumori
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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