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Methacholine Challenge Test in School Children With/Without Asthma RISKA

Recruitingn/aAges 7 Years - 15 YearsAllHelsinki University Central Hospital
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In plain words

What the trial is, and whether it could suit you

The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Healthy Controls * โ€ข Aged 7-15 years, both sexes * No diagnosis of asthma in childhood * No inhaled asthma medication during the previous 2 years * No wheezing or shortness of breath during the previous 2 years * Written informed consent from the participant and guardian Inclusion Criteria: Children with Asthma * Aged 7-15 years, both sexes * Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9) * Inhaled corticosteroid treatment for at least 6 months * Either: * Well-controlled asthma (c-ACT/ACT score โ‰ฅ20) and no clinical need to intensify medication, or * Poorly controlled asthma with physician-confirmed need for intensified asthma medication Exclusion Criteria: * โ€ข Premature birth before 32 gestational weeks * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma) * Severe underlying illness such as malignancy * Beta-blocker medication * Active immunological disease
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What it tests

  • Not listed
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Where

1 site
HUS Skin and Allergy Hospital
Helsinki, Finland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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