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Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)

RecruitingPhase 4Ages 50 Years - anyAllNational University Hospital, Singapore
NCT07031128 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

One of the most common major surgeries that older patients undergo is coronary artery bypass grafting surgery (CABG), which is performed in approximately 400,000 patients in the United States each year. CABG invokes a massive surgical stress response, with systemic epinephrine increasing 33-fold and norepinephrine increasing 3-fold. Initially, local tissue injury results in a sterile inflammation, releasing damage-associated molecular patterns (DAMPS). DAMPS activate neutrophils, bringing a cascade of cytokines, complement, and coagulation changes. Activation of nociceptors results in a neurometabolic response involving the sympathetic nervous system and hypothalamus-pituitary axis. This brings about systemic effects including changes in basal metabolic rate, hyperglycemia, lipolysis, negative nitrogen balance, and release of cytokines and complement. Although the surgical stress respons

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📋 Eligibility rules (as published)
Inclusion Criteria 1. Scheduled for elective CABG with cardiopulmonary bypass 2. Aged 50 years and above 3. Adequate cognitive function to be able to give informed consent Exclusion Criteria 1. Patients already taking AKG as a supplement 2. Substance abuse disorder either untreated or treated 3. Post-traumatic stress disorder, bipolar disorder, Schizophrenia, or any other untreated or poorly controlled mental health or mood disorder, or history of hospitalization due to mental health condition in the past 3 years, cognitively impaired patients 4. HIV/AIDS 5. Patients undergoing or scheduled to undergo chemotherapy or any other treatment for malignancy 6. Patients scheduled for immunosuppressant therapy for transplant 7. Patients with an active infection requiring antibiotic or antiviral therapy 8. Pregnant women / planning to conceive / breastfeeding women 9. Patients who are taking chronic anti-inflammatory drugs e.g., NSAIDS 10. Patients who are hypersensitivity to AKG or placebo or any components of the respective tablets to be administered
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What it tests

  • Alpha-ketoglutarate
  • Placebo
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Where

2 sites
National University Hospital
Singapore, Singapore
Singapore General Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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