🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol

Recruitingn/aAges 18 Years - 100 YearsAllGuy's and St Thomas' NHS Foundation Trust
NCT07032987 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable. ECMO is a life support machine that provides oxygen and removes waste gases (carbon dioxide) in very sick patients with severe heart or lung failure. About 300-400 patients per year receive ECMO in the UK. These patients are younger and generally more healthy compared to other critically ill patients. However patients that survive ECMO have long-term health problems. These include anxiety, memory problems, withdrawal from medicines, and mobility issues. These problems issues could all be related to the type and amount of sedation given. A sedation protocol is a way of guiding healthcare professionals how much sedation is given to patients in ICU. Too much sedation can cause confusion, halluc

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Stage 1 (multi-centre observational study): Inclusion Criteria: 1. Aged 18 years and older. 2. Receiving continuous IV infusions of analgosedation (opioids, benzodiazepines, and/or propofol). 3. Receiving ECMO for moderate to severe respiratory failure (PaO2/FiO2 (P/F) ratio \<20 kilopascals (kPa)) for ≤ 7 days during the week of recruitment. 4. Non-ECMO ICU patients (control group): must satisfy inclusion criteria 1 and 2, and have received mechanical ventilation for moderate to severe respiratory failure (P/F ratio \< 20kPa) for at least 48 hours OR mechanical ventilation for cardiovascular disorder (out of hospital cardiac arrest, following cardiothoracic or transplant surgery or percutaneous coronary intervention or acute heart failure). Exclusion Criteria: 1. Anticipated length of ICU stay in recruiting centre for less than 24 hours. 2. Withdrawal of life-sustaining treatment in the next 24 hours. Stage 2 (mixed methods study): Inclusion Criteria: 1. Healthcare professionals working at one of two ECMO centres (St Thomas' Hospital and Royal Brompton Hospital (part of Guy's and St Thomas' NHS Foundation Trust). 2. ECMO survivors (patients admitted to ICU and survived ECMO organ support) who have returned home, and recovered. 3. Family members of ECMO survivors, whose relative is no longer hospitalised. Exclusion Criteria: 1. ECMO survivors currently receiving treatment in hospital. 2. ECMO survivors with severe cognitive issues (issues with short-term memory and thinking). 3. ECMO survivors who cannot communicate in English. 4. Non-ECMO survivors and family members.
💊

What it tests

  • Not an intervention study
📍

Where

1 site
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy