💬In plain words
What the trial is, and whether it could suit you
Depression and bipolar disorder are frequent, debilitating conditions. Both are thought to be primarily caused by an impaired regulation of mood, which is why they are sometimes referred to as "mood disorders". However, the biological basis of mood remains poorly understood, which is a major limitation for the development of new treatments.
Recent work that combines neuroscience with mathematical models are promising to better understand mood and to link it to its biological basis, but they don't have any medical application yet. Can these models describe mood in a way that is relevant to mood disorders, and help doctors and psychologists predict subsequent clinical evolution? With the objective of extending this framework to real-life fluctuations and to assess its clinical relevance, this study will combine a neuroimaging session with a smartphone-based, longitudinal follow-up. Three
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
Common between groups (DD, BD, control and GP):
* Having given informed and written consent
* Being covered by social security
For patients with depressive disorder (DD):
* Having been diagnosed with characterized depressive episode (F32, F33, F34) according to the ICD-10, by a psychiatrist, or having presented this diagnosis during the past 12 months
For patients with bipolar disorder (BD):
* Presenting a diagnosis of bipolar mood disorder (F31) according to ICD-10, by a psychiatrist
* Having presented a mood episode (F31.0 - F31.6) diagnosed during the past 12 months by a psychiatrist
Exclusion Criteria:
Common between groups (DD, BD, control and GP):
* Inability to carry out daily monitoring on mobile application for 12 months
* legal protection measure (guardianship or curatorship)
For control group:
* Current diagnosis of psychiatric disorder in ICD-10 (F20-F98) or prescription of psychotropic treatment
* History of depression (F32)
* Syndrome of dependence on a psychoactive substance other than tobacco
* Neurological history (in particular history of stroke, coma, epilepsy, neuro- inflammatory, or neuro-degenerative disease)
* Inability to carry out daily monitoring on mobile application for 12 months
For patients and healthy volunteers for whom an MRI (without injection of contrast agent) is proposed
* Contraindication to MRI: cardiac pacemaker not compatible with MRI, heart valve implant, implant or metallic foreign body
* Pregnant woman (at the time of MRI)
💊
What it tests
- Brain magnetic resonance imaging (MRI) with structural (anatomical) and functional sequences (optional)
- Computerized cognitive tests
- Daily longitudinal monitoring by mobile MOODELING application
- Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences
Paris, France
Assistance Publique - Hôpitaux de Paris GH Pitié-Salpêtrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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