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Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques

Recruitingn/aAges 19 Years - anyAllYonsei University
NCT07035587 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a combined prospective and retrospective observational study aiming to validate a highly sensitive and specific blood-based method for the early diagnosis and post-treatment monitoring of multiple cancers. The study leverages a newly developed sequencing method to improve the detection of circulating tumor DNA (ctDNA) in blood, focusing on enhancing sensitivity and specificity in clinical applications. The study targets patients with ovarian, lung, pancreatic, colorectal, esophageal, breast, kidney, bladder, and gastric cancer, as well as healthy controls with asymptomatic gallstones, benign polyps, or individuals undergoing routine medical screening. Blood samples will be analyzed for cell-free DNA (cfDNA), RNA, and protein profiles. A key objective is to determine how much the newly developed method increases the sensitivity and specificity of ctDNA detection, especially in ea

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 19 years * Voluntarily agreed to participate and provided informed consent * Able to donate blood without health risks * Underwent or is scheduled to undergo surgery or chemotherapy for therapeutic purposes for cancer (for cancer group) * Diagnosed with one of the following cancers: ovarian, lung, pancreatic, colorectal, esophageal, breast, bladder, kidney, or gastric cancer * Control group: asymptomatic individuals with gallstones or benign polyps, or subjects undergoing routine health screenings * Control group must have confirmed benign findings through imaging (ultrasound, CT, LDCT, colonoscopy) Exclusion Criteria: * Age \< 19 years * Patients with mental retardation or severe psychiatric disorders affecting informed consent * History of HIV, HTLV, or syphilis infection * History of other malignancy within 5 years (for cancer group) * No somatic mutation detected in tumor or pre-treatment cfDNA (for cancer group) * Control group with any past or current cancer diagnosis * Control group with high-grade adenoma, symptomatic gallstones/polyps, or recent (\<6 months) abdominal surgery * Pregnant or breastfeeding women * Any other reason deemed inappropriate by the investigator
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What it tests

  • Serial Blood Sampling for Molecular Profiling
  • One-Time Blood Sampling for Molecular Profiling
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Where

1 site
Department of Pharmacology, Yonsei University College of Medicine
Seoul, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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