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PARLAR-02 Trial:Modified Transanal Drainage Tube Use for Preventing Anastomotic Leakage

RecruitingNAAges 18 Years - 80 YearsAllThird Military Medical University
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In plain words

What the trial is, and whether it could suit you

Surgical resection remains the primary treatment for rectal cancer, but the postoperative incidence of anastomotic leakage (AL) is relatively high. AL not only increases the medical burden on patients, prolongs hospital stays, raises the need for secondary surgery, and elevates perioperative mortality, but also increases the long-term risk of local recurrence and reduces survival rates. There is an urgent need for a simple, effective treatment method that minimizes the burden on patients to prevent anastomotic leakage. The preoperative placement of a transanal drainage tube (TDT) is believed to effectively drain gas and feces from the intestinal lumen, thereby reducing intestinal pressure and alleviating tension at the anastomotic site, thus preventing AL. Previous studies have shown that traditional drainage tubes cannot effectively prevent leakage. Given the limitations of existing re

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📋 Eligibility rules (as published)
Inclusion Criteria: * Rectal adenocarcinoma (confirmed by pathology); * Tumor location: The lower edge is ≤10 cm from the anal verge; * Age: ≥18 and ≤80 years old; * ASA ≤3 ; * After assessment, laparoscopic/robotic sphincter - preserving surgery for rectal cancer is feasible; * T2 - 4N0 - 2M0\~T0 - 1N1 - 2M0 \& non- local recurrence; * Signed informed consent form; * Able to understand the risks of participating in the trial. Exclusion Criteria: * Emergency surgery; * Presence of multiple primary colorectal cancers; * History of long - term use of immunosuppressants or corticosteroids; * Patients with severe mental illness or uncontrolled infection before surgery; * Pregnant or breastfeeding women; * Bowel obstruction before surgery; * BMI ≥35.0
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What it tests

  • Modified Transanal Drainage Tube
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Where

1 site
Army Medical Center (Daping Hospital)
Yuzhong, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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