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Coronary Evaluation And Guided Lesion Exploration Using Photon-counting CT and Intracoronary Imaging Techniques

Recruitingn/aAges 18 Years - anyAllUniversitaire Ziekenhuizen KU Leuven
NCT07036770 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study evaluates the diagnostic accuracy and limitations of photon-counting computed tomography (PCCT) in characterizing coronary plaque, with comparisons to optical coherence tomography (OCT) and intravascular ultrasound (IVUS). The objective is to assess whether cardiac ultra-high resolution (UHR) PCCT -with its improved spatial resolution and superior soft tissue contrast relative to conventional CT- can serve as a reliable, non-invasive alternative for coronary plaque assessment and support clinical decision-making. A total of 100 patients with either acute or chronic coronary syndrome will be enrolled, including 40 individuals with suspected in-stent restenosis and 10 patients one year post-percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). All participants will undergo invasive coronary angiography based on current European Society of Cardiology guideli

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📋 Eligibility rules (as published)
Inclusion criteria: Participants eligible for inclusion in this study must meet all of the following criteria: 1. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures. 2. At least 18 years of age at the time of signing the Informed Consent Form (ICF). 3. Patients presenting with suspected acute coronary syndrome (UA or NSTEMI) or chronic coronary syndrome (stable angina or silent ischemia). Exclusion criteria: Participants eligible for this study must not meet any of the following criteria: 1. Patients presenting with STEMI. 2. Haemodynamically unstable patients. 3. Unstable ventricular arrhythmias. 4. Killip class III-IV heart failure. 5. Creatinine clearance \<30 ml/min/1.73 m2 (as calculated by CKD-EPI formula 2009 for estimated GFR) and not on dialysis. Note: patients dependent on long-term dialysis are eligible for enrolment irrespective of their creatinine clearance levels. 6. Severe coronary vessel tortuosity. 7. Subject has known hypersensitivity to radiocontrast dye or that cannot be adequately pre-medicated. 8. Female who is pregnant or breast-feeding.
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What it tests

  • Coronary CT scan using photon-counting CT
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Where

1 site
UZ Leuven
Leuven, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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