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CBT Effects on Neural, Physiological, and Attentional Responses in Anorexia Nervosa

RecruitingNAAges 18 Years - 35 YearsFemaleIstanbul Nisantasi University
NCT07037017 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized controlled trial investigates the neurophysiological, physiological, and attentional effects of Cognitive-Behavioral Therapy (CBT) in individuals with restrictive-type anorexia nervosa (AN). The study compares two groups: one receiving a 12-week CBT intervention, and one placed on a waitlist (no active treatment during the study period). All participants undergo pre- and post-intervention assessments using electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking while exposed to visual stimuli related to food, body image, and self-appearance. The primary outcomes include neural changes in attention and emotional processing (P300, LPP, frontal alpha asymmetry), physiological arousal (skin conductance), and visual attention biases (fixation duration and gaze distribution). The aim is to determine whether CBT leads to measurable improvements in neurobiolo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female participants aged 18 to 35 * Meeting DSM-5 diagnostic criteria for restrictive-type anorexia nervosa * Body Mass Index (BMI) between 15.0 and 18.5 * Medically stable to participate in psychological and neurophysiological assessments * Willingness to participate in weekly therapy sessions (for the CBT group) and to complete pre- and post-assessments * Ability to provide informed consent Exclusion Criteria: * Current or past diagnosis of bulimia nervosa, binge-eating disorder, or other eating disorders * Presence of comorbid severe psychiatric disorders (e.g., psychosis, bipolar disorder, substance use disorder) * History of neurological illness or traumatic brain injury * Use of psychotropic medication within the last 6 weeks * Prior participation in structured Cognitive-Behavioral Therapy for an eating disorder * Pregnancy * Visual or neurological impairments that would prevent accurate EEG, GSR, or eye-tracking recordings
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What it tests

  • Cognitive-Behavioral Therapy
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Where

1 site
Üsküdar University Neuro Marketing Lab.
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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