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Understanding Cycles to Improve Women's Health

Recruitingn/aAges 18 Years - 39 YearsFemaleUniversity Hospital, Montpellier
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In plain words

What the trial is, and whether it could suit you

Introduction: The C-HEALTH study investigates how environmental and socio-economic conditions affect women's menstrual cycles and reproductive health. Aim: To compare progesterone levels during the luteal phase among women from different socio-economic backgrounds living in rural and urban areas in southern France. Methods: This is a prospective observational study involving 320 healthy women of reproductive age. * Hormones (progesterone, estradiol) will be measured daily in saliva. * Inflammation (Protéine C Réactive: CRP) will be measured five times per cycle via blood drops. * Participants will wear a smart ring to monitor body temperature and activity. * Daily symptoms and lifestyle data will be collected. * Environmental exposures (pollution, stress, living conditions) will be assessed and linked to menstrual health outcomes.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Woman of childbearing age (18-39 years) * Woman not using hormonal contraception for at least 6 months * Woman with semi-regular menstrual cycles between 21 and 45 days inclusive * Woman with no known history of infertility * Woman working in the same environment (urban/rural) as her place of residence * Knowledge of the dates of periods over the last 3 cycles * Woman who has a freezer at -20°C Exclusion Criteria: * Diagnosis by a physician of one or more of the following comorbidities: Polycystic ovarian syndrome (PCOS), Endometriosis, Adenomyosis, Diabetes or thyroid disease, Hormone-dependent gynecological cancers (breast, endometrium, ovaries), Coagulation diseases (von Willebrand), Chronic liver failure, chronic renal failure, heart disease, autoimmune disease, Autism, Diagnosis and/or treatment for a psychiatric illness * Chronic exposure to cocaine, amphetamine/methamphetamine, morphine or ecstasy within 30 days prior to inclusion * Chronic exposure to THC within 7 days prior to inclusion. * Person who is not comfortable with self-sampling (hematophobia or other) * No access to a smartphone * No possibility of wearing a connected ring for at least 60 days 22h/24h * Pregnant or breastfeeding woman * Woman who gave birth or breastfed in the 2 months before the study * Person who moved less than 2 years before the study (does not concern participants who moved in the same environment (rural or urban, less than 20 km) * Person unable to read French * Failure to obtain informed consent * Person not benefiting from a national health insurance scheme * Person under legal protection, guardianship or curatorship * Person participating in other research involving the human person
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What it tests

  • Self-saliva sampling
  • Self-collection of dried blood spots
  • Wearing the connected ring
  • Ovulation test
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Where

1 site
Institute of Evolutionary Science of Montpellier
Montpellier, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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