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Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing

Recruitingn/aAges 20 Years - 60 YearsAllPeking University First Hospital
NCT07039500 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are: 1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness? 2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake? 3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear? Researchers will compare two groups: * 50 adults with severe OSAHS (diagnosed by sleep tests) * 50 healthy adults matched by age and gender Participants will: * Complete hearing tests (MoCA) * Undergo a 1-night sleep test (PSG) * Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room: * Pas

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📋 Eligibility rules (as published)
Inclusion Criteria: All Participants: * Aged 20-60 years * Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram) * MoCA score ≥26 * Willing to complete EEG testing OSAHS Group Additional: \- PSG-confirmed severe OSAHS (AHI \>30 events/hour) Control Group Additional: * Self-reported absence of snoring/sleep disorders * No prior OSAHS diagnosis Exclusion Criteria: All Participants: * History of: * Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders * Middle/inner ear diseases (otitis media, acoustic neuroma, etc.) * Cognitive impairment or depression/anxiety disorders * Chronic steroid use * Systemic inflammatory diseases or malignancies * Pregnancy or suspected pregnancy (self-reported)
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What it tests

  • Not listed
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Where

1 site
Peking University First Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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