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Development and Validation of an Ovarian Cancer Risk Prediction Model for Family Members of Ovarian Cancer Probands

Recruitingn/aAges 18 Years - anyFemalePeking University Third Hospital
NCT07039552 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ovarian cancer is the gynecological malignancy with the highest fatality rate, seriously threatening the life and health of women. One of the main reasons for its high fatality rate is that approximately 70% of patients are diagnosed at an advanced stage. Fortunately, about 1/5 of ovarian cancers are associated with genetic factors, providing us with an opportunity to screen high-risk populations and thereby prevent and diagnose the disease at an early stage and reduce the disease burden. Currently, research related to hereditary ovarian cancer in China is still very scarce, and clinical practice relies on data from foreign studies. However, hereditary tumors have distinct regional and ethnic characteristics, making it urgent to conduct clinical research based on the Chinese population to guide clinical practice in China. Current research suggests that approximately 50% - 60% of heredit

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📋 Eligibility rules (as published)
Inclusion Criteria: * Pathologically diagnosed with ovarian malignant tumor. * Identified as carriers of BRCA1/2 germline pathogenic or likely pathogenic mutations through genetic testing, in accordance with the "Standards and Guidelines for the Interpretation of Sequence Variants" (2015 Edition) of the American College of Medical Genetics and Genomics (ACMG). * Age of 18 years or older. ④ Voluntary participation in this research and signing of the informed consent form. Exclusion Criteria: * ① Patients who refuse to provide necessary information.
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What it tests

  • risk-reducing salpingo-oophorectomy (RRSO)
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Where

1 site
Peking University Third Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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