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Comparison of Two-Position and Four-Position Cervical Injection Techniques for Sentinel Lymph Node Mapping in Endometrial Cancer Using Methylene Blue

RecruitingNAAges 18 Years - 75 YearsFemaleDokuz Eylul University
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In plain words

What the trial is, and whether it could suit you

This clinical trial evaluates lymph node mapping in newly diagnosed endometrial cancer patients undergoing surgery. The standard technique uses a 2-point methylene blue cervical injection. The study aims to determine if increasing injection points improves mapping success.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Individuals diagnosed with stage I endometrial cancer based on CT and PET-CT imaging. * Individuals with a pathologically confirmed diagnosis of stage I endometrial cancer. Exclusion Criteria: Medical Conditions * Individuals diagnosed with dementia. * Individuals with allergies to methylene blue or iodine. * Individuals who have received active treatment for another malignancy within the past five years. * Inability to successfully perform PLD (pelvic lymphadenectomy) or history of prior PLD. * Women with multiple and confluent lymph nodes identified as positive on FDG-PET/CT (such cases are not considered stage I). Cancer-Related Conditions * Individuals with clinically or radiologically identified positive lymph nodes or metastatic disease. * Individuals with a history of pelvic dissection and/or radiation therapy. * Individuals with advanced cervical or uterine cancer. * Individuals with T3/T4 lesions. * Individuals with cervical tumors larger than 2 cm. Organ Dysfunction • Individuals with hepatic dysfunction and a MELD score ≥ 10 and creatinine ≥ 2·0 mg/dl patients.
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What it tests

  • Sentinel Lymph Node Detection/Cervical Methylene Blue Injection
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Where

2 sites
Ankara University
Ankara, Turkey (Türkiye)
Dokuz Eylul University
Izmir, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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