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Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness

RecruitingNAAges 60 Years - 80 YearsAllSt. Anne's University Hospital Brno, Czech Republ…
NCT07042087 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 60-80 years * Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI) * mini-mental-scale (MMSE) score between 24-30 * Positive plasma pTau217 biomarker * Stable dose of iAChE therapy (if applicable) * Ability to participate in a 9-month intervention Exclusion Criteria: * Stroke or myocardial infarction within the past year * Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy) * Long-term psychiatric treatment (except well-managed depression) * Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy) * Severe sensory or motor impairment preventing protocol participation * Active cancer treated within the past 5 years * Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation) * Concurrent participation in another clinical study * Unstable iAChE medication regimen * Substance or alcohol dependence
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What it tests

  • Mindfulness Yoga
  • Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern
  • Cognitive Training
  • Stretching
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Where

1 site
Fnusa/ Icrc
Brno, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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