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Natural History of Advanced Chronic Liver Diseases

Recruitingn/aAges 18 Years - anyAllChinese University of Hong Kong
NCT07042308 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 or above * Known ACLD, defined by: * LSM \> 10kPa or * Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy. Exclusion Criteria: * Current or past history of hepatocellular carcinoma (HCC) * History of liver transplantation * Asplenism or history of splenectomy * Serious medical illness with limited life expectancy of less than 6 months * Pregnancy * Unable to obtain or refusal of informed consent from patient
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What it tests

  • Transient elastography
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Where

1 site
Prince of Wales Hospital
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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