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Personalization of External Beam Radiation Therapy in Localised Tumours

Recruitingn/aAges 18 Years - anyAllEuropean Institute of Oncology
NCT07047495 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.

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📋 Eligibility rules (as published)
Inclusion criteria for prostate patients: * Unifocal infiltrating ductal breast carcinoma, non-special histotype * clinical stage T1-T2,N0 * No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent. * Patients aged \>18 years * Good general condition (ECOG 0-2) * Expected active treatment (crioablation or surgery or radiotherapy ). Exclusion Criteria: * Exclusion criteria for prostate patients: * Nodule involvement and metastasis (cN1 and/or cM1) * Concomitant inflammation of the intestine * Significant systemic diseases or ongoing oral anticoagulant therapy * Non-compliance of dose constraints in the treatment plan * Previous invasive cancer, unless the patient has had no disease for at least 3 years * Mental disorders that cannot ensure valid informed consent Exclusion criteria for breast patients: * Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma) * Male sex * High-risk mutation carrier patients * Bilateral breast cancer * synchronous distant metastases * Neoadjuvant therapy * autoimmune connective tissue diseases * previous radiotherapy to the chest * Mental disorders that cannot ensure valid informed consent * No previous thoracic radiotherapy
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What it tests

  • prostate patient
  • breast patients
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Where

1 site
European Institute of Oncology
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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