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Interventions for Silent Brain Infarction and Perioperative Neurocognitive Disorders in Cardiovascular Surgery

RecruitingNAAges 60 Years - anyAllChinese Academy of Medical Sciences, Fuwai Hospit…
NCT07048002 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

the purpose of the study is to investigate whether a combined anesthetic targets bundle, known as the NeuroFirst strategy, focused on neurological protection, can reduce the incidence of silent brain infarction (SBI) and perioperative neurocognitive disorders (PND) in patients undergoing cardiac surgery. Additionally, the trial will assess the safety of this strategy. The NeuroFirst target bundle incorporates multiple parameters, including mean arterial pressure (MAP), bispectral index (BIS), regional cerebral oxygen saturation (rSO2), and arterial inflow temperature during cardiopulmonary bypass. The primary question this study seeks to answer is: Does the NeuroFirst strategy reduce the incidence of SBI and PND in cardiac surgery? To address this, researchers will compare the NeuroFirst strategy with routine institutional practices based on published guidelines. Participants will be

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📋 Eligibility rules (as published)
Inclusion criteria: * Male or female adult patients aged 60 years or older * Receiving elective cardiovascular surgery with cardiopulmonary bypass * Written Informed consent provided Exclusion criteria: * Contraindication to MRI scanning * Not suitable for receiving interventions to achieve NeuroFirst target bundle * Unable to receive neuro-cognitive evaluation due to language, vision, or hearing impairments * Breastfeeding or pregnancy * Terminal illness with a life expectancy of less than 3 months * Mental or legal disability * current enrollment in other interventional study
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What it tests

  • Managements for NeuroFirst target bundle
  • Managements for institutional routine
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Where

5 sites
Beijing Chaoyang Hospital，Capital Medical University
Beijing, China
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China
Xuanwu Hospital,Capital Medical University
Beijing, China
Beijing Tiantan Hospital, Capital Medical University
Beijing, China
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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