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Progression Assessment of PXE-associated Alterations

Recruitingn/aAges any - anyAllUniversity Hospital, Bonn
NCT07048106 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This monocentric clinical observational study at the University Eye Hospital Bonn investigates the natural history and structural consequences of a diseased Bruch's membrane (BrM) in Pseudoxanthoma elasticum (PXE). The study includes four main objectives: 1. Direct Bruch's Membrane Alterations: Longitudinal analysis of BrM reflectivity using high-resolution OCT to assess correlations with disease progression 2. Choriocapillaris Flow Deficits: Evaluation of choriocapillaris (CC) perfusion in relation to BrM calcification, aiming to clarify whether CC deficits precede or result from BrM changes 3. Retinal Atrophy Progression: Monitoring the development and expansion of retinal atrophic areas over two years, including correlations with specific features like reticular pseudodrusen and hyperreflective spots 4. Genotype-Phenotype Correlation: Analysis of different ABCC6 gene mutations to ide

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📋 Eligibility rules (as published)
Inclusion Criteria for PXE cohort: * PXE based on the criteria of Plomp et al. * Clear ocular media * Ability to perform the tasks of the study protocol (i.e., holding the head still for image aquisition) Exclusion Criteria: * Any confounding ocular disease not associated with PXE * Systemic diseases hindering the study examinations
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What it tests

  • Not listed
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Where

1 site
Department of Ophthalmology, University Hospital Bonn, Germany
Bonn, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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