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Specimen and Clinical Data Collection Plan for LDCT Screening Participants

Recruitingn/aAges 20 Years - 74 YearsAllChung Shan Medical University
NCT07048236 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lung cancer remains the leading cause of cancer-related mortality in Taiwan and globally, with increasing incidence and the highest healthcare cost burden among cancers in Taiwan. Despite the widespread use of low-dose computed tomography (LDCT) for screening smokers, over half of lung cancer cases in Taiwan occur in never-smokers, highlighting the need for improved risk stratification. Current national LDCT screening programs do not collect comprehensive risk-related data, limiting their predictive accuracy. This project proposes a five-year, multi-center initiative to establish an integrated biospecimen and clinical data collection system. In its first year, a feasibility pilot will be conducted, followed by recruitment of 12,000 participants. Data collection will include biospecimens (blood, urine, tissue), genomic and proteomic analyses, imaging, and detailed questionnaires covering

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📋 Eligibility rules (as published)
Inclusion Criteria: Previous heavy smokers According to The Lung Cancer Early Detection Program in Taiwan: Adults aged 50 to 74 years with a smoking history of at least 20 pack-years, who are either current smokers or have quit smoking within the past 15 years. Current smokers must agree to participate in a smoking cessation program. First-degree relatives of lung cancer patients According to The Lung Cancer Early Detection Program in Taiwan: Men aged 45 to 74 years and women aged 40 to 74 years who have a biological parent, child, or sibling diagnosed with lung cancer. Individuals who currently smoke must agree to participate in a smoking cessation program. Exclusion Criteria: 1. Pregnancy 2. History of chest computed tomography (including low-dose CT) within the past 12 months. 3. Previous diagnosis of lung cancer 4. Inability to undergo thoracic biopsy or surgery 5. Inability to complete the scan procedure, such as due to being unable to hold their breath. 6. Unexplained hemoptysis within the past month 7. Chest X-ray within the past month showing a clearly suspicious lung lesion 8. Unexplained weight loss exceeding 6 kilograms within the past year
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What it tests

  • Specimen and clinical data collection
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Where

2 sites
Chung Shan Medical University
Taichung, Taiwan
Ministry of Health and Welfare Shuang-Ho Hospital
New Taipei City, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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