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Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals

RecruitingNAAges 18 Years - 50 YearsAllUniversity of Ljubljana
NCT07048509 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition. The study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and va

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📋 Eligibility rules (as published)
Inclusion Criteria: Normotensive participants inclusion criteria: * 18 - 50 years of age, BMI \< 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\< 120 mmHg systolic and/or \< 80 mmHg diastolic BP) * Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \& Bull, 2006; Lim et al., 2012) * No prescribed medication and absence of chronic diseases Inclusion criteria for prehypertensive individuals: * 18 - 50 years of age, BMI \< 30 * Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria * Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ) * No prescribed medication and absence of chronic diseases Exclusion Criteria: * Blood pressure out of the optimal range (normotensives) * High level of phyisical activity (moderate or high active according to GPAQ) * Hypotension * Chronic diseases * Prescribed medication * Lower extremity injury in the last six months * Menopause * Absence of normal menstrual cycle * Pregnancy * Smoking
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What it tests

  • Control-no treatment
  • Exercise
  • Exercise
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Where

1 site
University of Ljubljana, Faculty of sport
Ljubljana, Slovenia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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