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Perioperative Intravenous Nimodipine Trial

RecruitingNAAges 18 Years - 75 YearsAllUniversity of Ioannina
NCT07048522 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The role of perioperative IV administration of nimodipine, an L-type calcium channel antagonist which is capable of crossing the blood-brain barrier, on peri-operative opioid and anesthetics requirements, pain intensity, opioid-related side effects and early postoperative bowel mobility in patients undergoing surgical treatment for bowel cancer with open radical colectomy remains scarcely explored. A prospective double-blind, randomized controlled trial investigating the effect of perioperative IV administration of nimodipine in patients undergoing open colectomy for cancer treatment is therefore conducted.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients scheduled for open surgical treatment of bowel cancer at the General Hospital of Patra Exclusion Criteria: * Age \< 18 years, \> 75 years * American Society of Anesthesiologists (ASA) physical status \> III * Allergy to nimodipine * Inability to provide informed consent * Known severe renal insufficiency * Known severe bradyarrhythmia * Daily opioid consumption the last 7 days before surgery * Pain intensity assessed using the Numerical Rating Scale (NRS; 0-10), with scores greater than 5 reported on more than half of the days during the past month.
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What it tests

  • Nimodipine
  • Isotonic Saline
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Where

1 site
St. Andrews General Hospital of Patras, GREECE
Pátrai, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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