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Toxicity Markers to Trastuzumab-Deruxtecan (T-DXd) In Patients With Advanced Breast Cancer

Recruitingn/aAges 18 Years - anyAllEuropean Institute of Oncology
NCT07049133 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

the anti-Human Epidermal Growth Factor Receptor 2 (HER2) Trastuzumab-Deruxtecan (T-DXd) has shown impressive clinical activity in pretreated patients with metastatic breast cancer (MBC) but is also associated with a non-negligible rate of adverse events that may lead to treatment discontinuation and/or the onset of pneumonitis/interstitial lung disease (ILD) The aim of the study is to identify and describe potentially predictive markers related to the onset of relevant T-DXd-related toxicities

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female, aged at least 18 years. * Histologically documented invasive breast cancer, either HER2-positive or HER2-low/ultralow. * Candidate to receive T-DXd as per standard practice. * Consent for the provision of blood samples for exploratory analyses. Exclusion Criteria: * Operable, non-metastatic breast cancer * Unwillingness to provide additional blood draws
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What it tests

  • T-DXd toxicity marker identification
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Where

1 site
European Institute of Oncolgy
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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