🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Systematic Adjunction of Vasopressine in Septic Shock

RecruitingPhase 3Ages 18 Years - anyAllAssistance Publique Hopitaux De Marseille
NCT07052084 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Septic shock is a syndrome associated with severe infection and a mortality rate of approximately 45%. In line with current recommendations, norepinephrine is the first-line vasopressor used in patients with septic shock. In a previous study, norepinephrine doses above 1 µg/kg/min were associated with mortality rates over 90%. In the same study, doses above 0.3 µg/kg/min were associated with a mortality rate of 40%. An increased mortality compared to the general 40% mortality of septic shock appears to be associated with norepinephrine doses as low as 0.3 µg/kg/min. Vasopressin stimulates V1 receptors, primarily located on vascular smooth muscle cells. When V1a receptors are stimulated, they induce vasoconstriction by activating protein kinase C via a Gq protein and various second messengers. Its use is validated in refractory shock states by international guidelines as a second-line v

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Patient aged 18 or over * Patient who has consented to take part in the research or patient whose close relative has consented to take part in the research or, failing that, patient being included in an emergency situation * Patient in septic shock with adapted cardiac output * Patient in whom noradrenaline dosage has been greater than 0.3μg/kg/min for less than 12 hours * Patients benefiting from or affiliated to social security Exclusion Criteria: * Patient with acute coronary syndrome * Patient with known history of acute coronary syndrome * Patient with suspected mesenteric ischemia * Patient with hyponatremia \< 130mmol/L, * Known allergy to vasopressin or its excipients * Minors * Pregnant women * Patients under legal guardianship or curatorship * Patients under judicial protection.
💊

What it tests

  • Vasopressin administration
  • Sodium chloride administration
📍

Where

3 sites
Centre Hospitalier du Pays d'Aix
Aix-en-Provence, France
Assistance Publique - Hôpitaux de Marseille
Marseille, France
CHU de Nîmes - Carémeau
Nîmes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy