🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Finerenone in Patients With IgA-nephropathy: Prospective Interventional Trial

RecruitingNAAges 18 Years - anyAllBotkin Hospital
NCT07056595 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

: IgA-nephropathy is the most common glomerulonephritis with the unfavorable prognosis in patients with persistent albuminuria. Finerenone is a new nonsteroidal mineralocorticoid receptor antagonist that has demonstrated efficacy in reducing albuminuria in patients with CKD and type 2 diabetes in two major trials, FIGARO-DKD and FIDELIO. This finding supported the approval of finerenone by the U.S. Food and Drug Administration (FDA) for the treatment of chronic kidney disease (CKD). A subgroup analysis in the pooled FIDELITY trial demonstrated that in patients with CKD stages 1-4 and type 2 diabetes (T2D), the cardio- and nephroprotective effects of finerenone were independent of concomitant therapy with SGLT-2 inhibitors or GLP-1 receptor agonists. Thus, the role of finerenone in slowing CKD progression in T2D can be considered well-established. Given its albuminuria-reducing effects, f

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (\> 18 years) with the primary IgAN diagnosed by kidney biopsy; * Treatment with stable doses of iRAS or/and iSGLT2 inhibitors for at least 3 months prior inclusion into the trial; * Blood pressure \< 140/90 mm Hg * 24-hour urinary albumin excretion \> 300 mg Exclusion Criteria: * Kidney transplantation in medical history * Chronic hepatic disease, including hepatitis, malignant tumor, active malignancy; * Heart failure with ejection fraction \<40%; * Acute myocardial infarction and/or stroke less then 3 months before including in trial; * Presence ANCA in serum * Ongoing immunosuppressive treatment * eGFR \< 20 ml/min * Pregnancy and breastfeeding * Uncontrolled blood pressure
💊

What it tests

  • Finerenone
📍

Where

1 site
Botkin Hospital
Moscow, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy