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Cold Atmospheric Plasma for Moderate-to-severe Acne Vulgaris Study

RecruitingNAAges 18 Years - 40 YearsAllShenyang Medical College
NCT07056673 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acne vulgaris is a common, chronic inflammatory skin disease with complex pathogenesis and limited therapeutic options, especially for moderate-to-severe cases. Standard treatments-including topical and oral agents-are often constrained by side effects, antimicrobial resistance, and treatment resistance. Cold atmospheric plasma (CAP), a novel technology that generates reactive oxygen and nitrogen species, has demonstrated antimicrobial and tissue-regenerative properties in dermatology, but robust clinical evidence in acne management remains scarce. Existing data suggest promising efficacy and safety, yet its use in moderate-to-severe acne vulgaris has not been adequately investigated. This study aims to evaluate the efficacy and safety of two self-developed CAP devices as a potential innovative therapy for moderate-to-severe acne vulgaris.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18-40 years; * Clinically diagnosed with acne vulgaris, with moderate to severe disease (Pillsbury grade III or IV, lesion count ≥50); * Will agree to use effective contraception during the treatment period; * Will sign a written informed consent form. Exclusion Criteria: * Pregnant or breastfeeding women; * Known allergy to any active component of CAP; * Use of systemic antibiotics within 4 weeks prior to enrollment; * Presence of dyslipidemia or other severe systemic diseases; * Participation in other clinical trials within the past 3 months or currently enrolled in another clinical trial.
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What it tests

  • Active CAP therapy
  • sham CAP therapy
  • standard care based on the JAAD acne guidelines
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Where

1 site
the 989th Hospital of Chinese People's Liberation Army Joint Logistic Support Force
Luoyang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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