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Efficacy of Collagen Matrix for Peri-implant Soft Tissue Phenotype Modification

RecruitingNAAges 21 Years - anyAllMohammed Bin Rashid University of Medicine and He…
NCT07056959 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A stable band of keratinized mucosa (KM) around dental implants is thought to minimize tissue recession and provide resistance against mechanical, chemical, and microbial challenges, thereby preserving peri-implant tissue health. Soft tissue augmentation is often employed to enhance the soft tissue phenotype in such cases. While autogenous grafts such as free gingival grafts (FGG) remain the gold standard, xenogeneic collagen matrices (XCM) have emerged as promising alternatives, offering reduced patient morbidity and surgical time. This randomized controlled clinical trial aims to compare the clinical efficacy and patient-reported outcome measures (PROMs) of XCM versus FGG for soft tissue phenotype modification when performed during healing abutment connection around dental implants, with evaluations at both short-term (6 months) and long-term (1 and 2 years) intervals. Thirty particip

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 21 or over. * Insufficient KM width (\< 2 mm) at the buccal aspect of implants at time of healing abutment placement, either for single anterior or posterior implants. * Controlled oral hygiene (full-mouth plaque and bleeding scores ≤ 25% at baseline). * Good compliance and commitment to attend follow-up review appointments. * Willing to provide informed consent. Exclusion Criteria: * Smoking * Untreated localized or generalized periodontal diseases * Uncontrolled systemic diseases * Long term use of non-steroidal anti-inflammatory medications * History of malignancy, radiotherapy or chemotherapy * Collagen allergy * History of mucogingival surgery
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What it tests

  • Soft tissue substitute for peri-implant phenotype modification
  • Control Group - Free gingival graft for soft tissue augmentation
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Where

1 site
Dubai Dental Hospital
Dubai, United Arab Emirates
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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