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Light Therapy on Pain and Synovitis

RecruitingNAAges 40 Years - 80 YearsAllThe Hong Kong Polytechnic University
NCT07057063 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Knee pain is a common complaint among middle-aged and older adults, often leading to reduced mobility and diminished quality of life. Synovitis is a major underlying cause, present in up to 80% of individuals with moderate knee pain. While light therapy has shown anti-inflammatory and analgesic effects in preclinical studies, our prior animal experiments revealed that light therapy at 810 nm significantly alleviated inflammation and pain-like behaviors. These findings suggest a potential wavelength-specific therapeutic effects. However, it remains unclear whether such effects can be replicated in humans. This study aims to evaluate the efficacy of 810 nm light therapy, compared to sham treatment, in reducing knee pain and synovitis in patients with chronic knee pain and knee synovitis. Methods/design: This is a randomized, placebo-controlled clinical trial involving 90 part

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participants aged between 40 and 80 years * Able to provide written informed consent * Have experienced knee pain that persists or recurs for more than 3 months * A knee pain score of at least 30 mm on the 100-mm Visual Analogue Scale (VAS) during the past week * Ultrasound-measured knee synovitis ≥1 * Presence of knee OA according to criteria established by the American College of Rheumatology Exclusion Criteria: * Anticipated need for knee surgery within the next one year * Previous or planned knee replacement within the next one year * Knee surgery or other physical therapy in the previous 3 months * Use of intra-articular, intra-muscular, or oral corticosteroids in previous 4 weeks * Malignant tumors or other life-threatening diseases * Severe mental disorders, including but not limited to schizophrenia, bipolar disorder, or major depressive disorder, that may interfere with the participant's ability to comply with the study protocol or provide informed consent
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What it tests

  • 810 nm Light Therapy
  • Sham Light Therapy
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Where

2 sites
Buji Community Service Center, Longgang District
Shenzhen, China
The Hong Kong Polytechnic University
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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